منابع مشابه
Neddylating the Guardian Mdm2 Catalyzed Conjugation of Nedd8 to p53
The tumor suppressor and transcriptional regulator p53 is perhaps one of the most regulated proteins in the cell nucleus and is acted upon by a variety of protein kinases, acetylases, ubiqutin ligases and hydrolases, and SUMO-conjugating enzymes. Now new work suggests a role for an additional modification-neddylation-in negative regulation of p53 transcriptional activity.
متن کاملGrowth Control: p53, the Guardian Angel of Compensatory Proliferation
Compensatory growth, or regeneration, is used to replace damaged tissue during animal development. Recent work has revealed a new role for Drosophila p53 in the compensatory proliferation of cells that are needed to repair damaged tissues, a role that requires the non-apoptotic function of the caspase protease Dronc.
متن کاملSnapShot: p53 Posttranslational Modifications
P ho sp ho ry la ti o n N-Terminal: S6, S9, S15, T18, S20 ATM, DNAPK, • CK1 ERKs, ATR, p38 • kinase, mTOR, Chk1/Chk2, JNK, MAPKAP2, Hipk4 Activated by DNA damage, UV light, ionizing radiation, replicative senes• cence, or phosphatidylcholines. N-terminal phosphorylation causes p53 stabilization by inhibiting the p53• MDM2 interaction. Knockin mice carrying separate analogs to human Ser18/ • Ser...
متن کاملThe Maintenance of Epigenetic States by p53: The Guardian of the Epigenome
Commentary on: Leonova et al. p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs. PNAS, USA, 2012; in press. The functions of the p53 tumor suppressor gene and its protein are to ensure fidelity of cellular replicative processes so as to minimize mutational errors even in the presence of a wide variety of environ...
متن کاملDynamics of Posttranslational Modifications of p53
The latest experimental evidence indicates that acetylation of p53 at K164 (lysine 164) and K120 may induce directly cell apoptosis under severe DNA damage. However, previous cell apoptosis models only studied the effects of active and/or inactive p53, that is, phosphorylation/dephosphorylation of p53. In the present paper, based partly on Geva-Zatorsky et al. (2006) and Batchelor et al. (2008)...
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ژورنال
عنوان ژورنال: Journal of Molecular Cell Biology
سال: 2019
ISSN: 1759-4685
DOI: 10.1093/jmcb/mjz060